WebResults: TvLG is composed of a polyrhamnose backbone with branches of poly-N-acetyllactosamine that are involved in attachment to host epithelium. Conclusion: TvLG has a unique structure among solved parasite glycans. Significance: This work provides a template to analyze TvLG from T.vaginalis with different binding properties. WebWe previously identified the 12-gene GAC biosynthesis gene cluster and determined that the glycosyltransferase GacI was required for addition of the GlcNAc side chain to the …
Virulence Role of the GlcNAc Side Chain of the Lancefield Cell Wal…
WebJan 19, 2024 · With new strains of Acinetobacter baumannii undergoing genomic analysis, it has been possible to define regions of genomic plasticity (RGPs), encoding specific adaptive elements. For a selected RGP from a community-derived isolate of A. baumannii, we outline sequences compatible with biosynthetic machinery of surface polysaccharides, … Webpolyrhamnose backbone. In this work, we have analyzed the binding of the O-antigen polysaccharide of S. flexneri to TSP of the bacteriophage Sf6 (Sf6TSP) to examine how extended polysaccharide chains interact specifically with a protein surface. The O-antigen consists of a carbohydrate backbone with high (75 %) rhamnose content, and a growing ... in case you were wondering meaning
Immunobiology of the Classical Lancefield Group A Streptococcal ...
WebIn S. pyogenes, elucidation of the mechanism of side-chain GlcNAc addition to the polyrhamnose backbone of GAC revealed that this process relies on a four-component … WebApr 1, 2024 · In GAS, gacI, gacJ, gacK and gacL encode the machinery to generate and add the GlcNAc side-chain to the polyrhamnose backbone 11,15, whereas the genes required … WebJan 30, 2024 · The GAC biosynthesis gene cluster is ubiquitous among 520 GAS isolates from global sources, representing 105 GAS emm serotypes, and the relative contribution of GAC to virulence in non-M1 serotypes appears to depend on the quorum of other virulence factors that each strain possesses. ABSTRACT Classification of streptococci is based … dvds with olympic tie ins