Incidence of rhabdomyolysis with daptomycin
WebTo determine the incidence and characteristics of significant adverse effects in patients receiving high-dose daptomycin with severe renal dysfunction. ... One patient experienced significant CK elevation while on daptomycin therapy with rhabdomyolysis; however, daptomycin was continued as there was an alternative explanation for an elevated CK ... WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects were thought to be minimized by once-daily dosing. Prior elevations in serum CPK levels and/or myopathy have generally occurred at least 7 days after the initiation of therapy.
Incidence of rhabdomyolysis with daptomycin
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WebMar 19, 2024 · The meta-analysis found that statin use significantly increased the incidence of DAP-related rhabdomyolysis compared with no statin use (6.2% vs 13.0%; odds ratio [OR] 3.83; 95% CI 1.43, 10.26) but had no significant effect on the incidence of DAP-related myopathy (6.6% vs 6.0%). WebOct 5, 2024 · The primary outcome was overall incidence of creatine phosphokinase (CK) elevation, myopathy and rhabdomyolysis. Results and discussion A total of 74 patients who received daptomycin therapy were screened with 50 included in the study.
WebNov 17, 2024 · However, the risk of developing rhabdomyolysis from statin therapy is very low, around 1.5 for each 100,000 people taking statins. Rhabdomyolysis or milder forms … WebRhabdomyolysis is a well-known clinical syndrome of muscle injury associated with myoglobinuria, electrolyte abnormalities, and often acute kidney injury (AKI). The pathophysiology involves injury to the myocyte membrane and/or altered energy production that results in increased intracellular calcium concentrations and initiation of destructive …
WebEarly-onset rhabdomyolysis related to daptomycin use. Early-onset rhabdomyolysis related to daptomycin use Int J Antimicrob Agents. 2007 Nov;30(5):472-4. doi: … WebMar 19, 2024 · The meta-analysis found that statin use significantly increased the incidence of DAP-related rhabdomyolysis compared with no statin use (6.2% vs 13.0%; odds ratio …
WebThe incidence of myopathy and rhabdomyolysis were highest during the first year and then decreased during the subsequent years of treatment. In another clinical outcomes study …
WebSep 29, 2024 · Introduction. Daptomycin is a lipopeptide antibiotic often used for the treatment of methicillin-resistant Staphylococcus aureus (MRSA). Despite its clinical utility, there have been a few reports of rhabdomyolysis related to daptomycin use [1,2].In this report, we present a case of rhabdomyolysis, severe hyperkalemia, and acute kidney injury … dwits mshpWebMar 1, 2024 · irregular heartbeat. irritability. itching in the genital or other skin areas. itching, pain, redness, swelling, tenderness, or warmth on the skin. lightheadedness. loss of appetite. loss of consciousness. lower back or side pain. mood changes. crystal lattice of copperWebDec 11, 2024 · Daptomycin is associated with an increased incidence of myopathy and rhabdomyolysis. There have been cases reported in patients with and without acute renal … dwits missouriWebNov 10, 2024 · A typical adverse reaction of daptomycin is creatine phosphokinase (CPK) elevation, which occurred in 6.7% of patients in a phase 3 study [ 2 ]. This adverse reaction is dose-dependent, and Lai et al reported a significantly higher incidence of CPK elevation at doses of ≥8mg/kg than at <8mg/kg [ 3 ]. dwits moWebThere have been reports of myopathy, rhabdomyolysis, and increased creatine phosphokinase (CPK) levels in patients taking daptomycin, which increased when daptomycin was given more than once per day. crystal launcher 1.18WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects … crystal lattice structure of siliconWebDaptomycin, a cyclic lipopeptide antibiotic, has bactericidal activity against Gram-positive organisms ... Although daptomycin causes unique adverse drug reactions such as elevation of creatine phosphokinase or rhabdomyolysis, the detailed ... and incidence of CPK elevation. Second, an in vitro pharmacological study was conducted using cul- crystal lattice + crystal structure