Human cyclin d1 promoter
WebThe human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, and so on. The extracellular signals ... Web24 nov. 1995 · HeLa cells were transfected with S phase-specific promoter-CAT plasmids (human DNA polymerase α, human cyclin D1, human thymidine kinase, or hamster …
Human cyclin d1 promoter
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WebEnhanced p53 can inhibit proliferation and clonogenicity of PCa cells by modulating the expression of Cyclin D1 and cyclin-dependent kinase (CDK). Materials and methods Design of dsRNAs The dsRNAs used in this study possess two-nucleotide 3′ overhangs and were chemically synthesized by RiboBio Co., Ltd. (Guangzhou, People’s Republic of …
WebCyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1/S phase transition.Cyclin D protein is … Webbut did reduce cyclin D1 promoter activity, suggesting that Cdx1 acts to diminish cyclin D1 gene transcription. We conclude that Cdx1 reduces the proliferation of human colon …
WebIn the present study, we have cloned the human cyclin D1 gene and analysed the structure and function of 3kb of its 5'-flanking region. Several regulatory regions … Web11 mei 1999 · The cyclin D1 promoter was induced 12-fold by this β-catenin (Fig. 1 B) and was not affected by either the empty expression plasmid (Fig. 1 B; pA3) or the construct …
Web15 mei 2024 · The hypomethylation of the Cyclin D1 (CCND1) promoter induced by excess oxidative stress likely promotes the development of hepatitis B virus-associated …
Web28 sep. 1999 · The cyclin D1 promoter contains multiple regulatory elements [TRE, E2F, Oct, Sp1, and cAMP response element (CRE)] and some potential elements that may be … clicks blood pressure machine priceWebIn addition, the expressions of HOPX, p21, cyclin D1 and CDK4 in cells were detected with Western blot assay. Results: Bisulfite sequencing indicated that the CpG sites (cg218995965 and cg24862548) in the HOPX promoter region showed significantly higher methylation in breast cancer tissues. bnd23Web6 apr. 2024 · Introduction. Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, is the major cyclin involved in transition of cells from the G1 to S phase and plays a vital role in the pathogenesis of cancer [1, 2].The amplification and/or overexpression of CCND1 have frequently been found in a variety of cancers [3–14].There are a large number of … bnd1comWeb2 apr. 2024 · A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair, generating improved genetically stable human induced pluripotent stem … clicks bluff contact numberWebCyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Function. Cyclin … bnd25·comWeb2 feb. 2013 · Other studies have shown that MUC1-C occupies the cyclin D1 promoter with the β-catenin/TCF7L2 complex and promotes cyclin D1 ... Ahmad R, Jin C, Kosugi M, Alam M, Joshi M, et al. MUC1-C Oncoprotein Induces TCF7L2 activation and promotes cyclin D1 expression in human breast cancer cells. J Biol Chem. 2012:10703–10713. [PMC ... clicks blueberry square contactWebMoreover, STAT3 and cyclin D1 protein expression was analyzed because both proteins are downstream targets of PPARγ-mediated signaling and are essential for cell cycle progression [21,22]. We found that PPARγ-overexpressing cells (Mahlavu-PPARγ) exhibited decreased cell growth rates ( Figure 2 A) and reduced STAT3 and cyclin D1 expression … bnd29