WebThis review summarizes the currently available methods of gene and cell therapy for epilepsy and discusses the development of these approaches. Currently, gene therapy … WebNational Center for Biotechnology Information

NPY and Gene Therapy for Epilepsy: How, When,... and Y

WebA highly targeted epilepsy gene therapy that impacts only hyperactive neurons and stops when seizures go away showed promise in mice and human brain organoids. WebGene therapy with AAV vectors carrying genes for neuropeptide Y and its receptor Y2 has been shown to inhibit seizures in multiple animal models of epilepsy. It is however unknown how the AAV serotype or the sequence order of these two transgenes in the expression cassette affects the actual parenchymal gene expression levels and the seizure ... floating frame cricut ideas

NPY and Gene Therapy for Epilepsy: How, When,... and Y

WebFeb 12, 2024 · Below, we briefly summarize the state of the art of vector development for gene therapy and the results of preclinical studies in epilepsy models. We then describe some recent advances that may be implemented in epileptology, moving the field closer to a much-awaited clinical application. WebApr 17, 2024 · We set out to develop an epilepsy gene therapy vector optimized for clinical translation. The gene encoding the voltage-gated potassium channel Kv1.1, KCNA1 , … WebNov 3, 2024 · In a chronic model of epilepsy, we achieved a greater decrease in seizure frequency than previously reported for gene therapy with constitutive promoters or with widely used antiseizure drugs (11–13, 43), and without deleterious effects on normal behaviors (Figs. 4 and 5). Given that the components of activity-dependent gene … floating frame canvas art