Bivalirudin and dialysis
WebStudy objective: To evaluate the safety, effectiveness, and dosing of bivalirudin for treatment of heparin-induced thrombocytopenia (HIT) in critically ill patients with hepatic and/or renal dysfunction. Design: Retrospective cohort study. Setting: University-affiliated medical center Patients: Eighteen patients older than 18 years who were admitted to the … WebOct 17, 2024 · The aPTT declined 11% during PIRRT session 1, but began to rise after dialysis ended and bivalirudin was adjusted to 0.11 mg/kg/h. The patient remained within the therapeutic range for the next 48 h undergoing 2 additional PIRRT sessions. During the second and third PIRRT sessions, aPTTs transiently declined by 24% and 6%, …
Bivalirudin and dialysis
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WebNov 16, 2005 · Bivalirudin was initiated by continuous intravenous infusion (range 0.03–0.2 mg/kg/h) and adjusted to an aPTT of 1.5–2.5 times patient baseline. The mean infusion rate was 0.1 mg/kg/h. The average duration of therapy was 7.8 (range 1–24) days. 7/42 (16.7%) of patients had overt bleeding and received ≥ 2 units of packed red blood cells ... WebJul 9, 2024 · “Bilvairudin has tremendous potential to supplant heparin for several reasons: It binds directly to thrombin, causing more predictable pharmacokinetics and eliminating the need for supplementing low antithrombin levels; it inhibits both circulating and clot-bound thrombin; and it is not associated with heparin-induced thrombocytopenia (HIT),” …
WebDec 15, 2024 · In particular, patients with renal insufficiency, old age, ... Bivalirudin might have more advantages, especially for patients with heparin-induced thrombocytopenia and high hemorrhage risk. The limitations in the present study were as follows: 1. Only the inpatients from the First People's Hospital of Yulin were enrolled in the present study ...
WebThe efficacy of bivalirudin has been well documented in the setting of percutaneous coronary intervention, but there are only few data on its use in chronic dialysis-dependent patients. Bivalirudin is mainly eliminated enzymatically (80%) and … WebMay 1, 2024 · Another retrospective study found that patients on intermittent hemodialysis or CRRT required lower doses than patients with normal renal function but higher doses than patients with Cl cr less than 30 mL/min not receiving dialysis. 26 In this study, average therapeutic dose of bivalirudin in the setting of CRRT was 0.07 mg/kg/h.
WebDec 15, 2024 · In dialysis-dependent patients, reduce off-dialysis infusion rate to 0.25 mg/kg per hour. Hepatic Impairment No specific dosage recommendations. Geriatric Patients No specific dosage recommendations. Detailed Bivalirudin dosage information Cautions for Bivalirudin Contraindications Active major bleeding.
WebJun 19, 2024 · Normal renal function and mild renal impairment: 25 minutes. Moderate renal impairment: 34 minutes. Severe renal impairment: 57 minutes. Dialysis: 3.5 … green zone whiston hospitalWebBest Body Shops in Fawn Creek Township, KS - A-1 Auto Body Specialists, Diamond Collision Repair, Chuck's Body Shop, Quality Body Shop & Wrecker Service, Custom … fob hondaWebSep 1, 2011 · An initial dose of bivalirudin 0.15-0.2 mg/kg/h, adjusted to an activated partial thromboplastin time (aPTT) of 1.5-2.5 times the baseline value, has been suggested. Initial dosing in patients... greenzone hydroponics and suppliesWebhalf-life – normal/ESRD (hrs) :13–37 minutes/ 57 minutes (310 minutes in dialysis patients on non-HD days) DOSE IN RENAL IMPAIRMENT GFR (mL/MIN) 30–50 Dose as in … fob honda accord 2000WebTraductions en contexte de "impaired renal function Doxorubicin" en anglais-français avec Reverso Context : Use in patients with impaired renal function Doxorubicin is metabolised largely by the liver and excreted in the bile. fob hoursWebThe disposition of bivalirudin was studied in PTCA patients with mild and moderate renal function and in patients with severe renal function. Drug elimination was related to glomerular filtration rate (GFR). Total body clearance was similar for patients with normal renal function and with mild renal impairment (60-89mL/min). Clearance fo bhruidWebThe City of Fawn Creek is located in the State of Kansas. Find directions to Fawn Creek, browse local businesses, landmarks, get current traffic estimates, road conditions, and … fobh property management